Etiologic factors and imaging features of cytotoxic lesions of the corps callosum
(Cloccs): A series of 5 patients

Imane Mahdar; Maimouna Banao; Kenza  Fathellah; Aicha Merzem; Belgadir Hasna; Nadia Moussali; Naima Elbenna

doi:10.5455/ajdi.20240309025956

Abstract
Cytotoxic Lesions of the Corpus Callosum (CLOCCS) are secondary lesions associated with various etiologies, including trauma, infection, and metabolic disorders. Recognizing these lesions is crucial as they can mimic primary callosal lesions such as ischemia. This retrospective study presents a series of five patients with CLOCCS, evaluating their clinical and radiological characteristics over a one-year period. Imaging, particularly MRI, plays a pivotal role in diagnosis, with diffusion-weighted sequences revealing characteristic features of cytotoxic edema. Clinical context, additional imaging findings, and patient history aid in distinguishing CLOCCS from other pathologies. The study highlights diverse etiologies contributing to CLOCCS, including trauma, infection (e.g., Malaria, COVID-19), and metabolic disorders. Treatment strategies depend on addressing the underlying cause. Understanding the spectrum of etiologies and imaging features of CLOCCS is vital for accurate diagnosis and appropriate management.

Key words: CLOCCS. MRI. Trauma. Infection.