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Original Article
Online Published: 25 Feb 2025
 


Microplastic Exposure Impairs Weight Gain, Reproduction, Blood Glucose Levels, and Organ Health in Rats (Rattus norvegicus)

Tajudeen Olanrewaju Yahaya, Titilola Fausat Salisu, Kabiru Musa, Hindatu Sani, Samuel Tadi, Ufuoma Shemishere, Anyebe Daniel, Nasiru Muhammad.


Abstract
Background: Emerging studies highlight growing concerns about the effects of microplastics on mammals, however further studies are needed to fully understand their health impacts. This study investigated the effects of microplastics on rats (Rattus norvegicus).
Methods: Thirty rats were divided randomly into five groups, each consisting of six animals. Group 1 served as the negative control, while Group 2 (positive control) was administered 10% lead acetate. Test rats in Groups 3, 4, and 5 were orally exposed to 1%, 5%, and 10% microplastic solutions, respectively. Over a 28-day period, the rats' body weights, blood glucose levels, reproductive performance, offspring survival rates, and mortality rates were monitored. Thereafter, the livers and kidneys of the rats were harvested for histopathological analysis.
Results: Rats dosed with 5% and 10% microplastics experienced weight increases of 4.73% and 4.06%, respectively, which were significantly lower (p < 0.05) than the 8.29% increase in the negative control group. Moreover, the 1%, 5%, and 10% groups had glucose increases of 30.17%, 38.09%, and 40.00%, respectively, which were significantly higher than the 16.00% increase observed in the negative control group. The negative control group had 15 offspring per birth, of which 12 survived; the 1% group had 13 offspring, of which 10 survived; the 5% group recorded 11 offspring and 6 survivors; and the 10% group recorded 9 offspring and 4 survivors. Histopathological examination revealed dose-dependent inflammation and necrosis in the kidneys and livers of exposed rats.
Conclusion: These findings indicate that microplastics exhibit toxic effects, emphasizing the need for strategies to reduce human exposure to these particles.

Key words: Blood glucose levels, Body weight, Inflammation, Microplastics, Necrosis.


 
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How to Cite this Article
Pubmed Style

Yahaya TO, Salisu TF, Musa K, Sani H, Tadi S, Shemishere U, Daniel A, Muhammad N. Microplastic Exposure Impairs Weight Gain, Reproduction, Blood Glucose Levels, and Organ Health in Rats (Rattus norvegicus). J Exp Lab Med. Online First: 25 Feb, 2025. doi:10.5455/JELM.20241203024659

Web Style

Yahaya TO, Salisu TF, Musa K, Sani H, Tadi S, Shemishere U, Daniel A, Muhammad N. Microplastic Exposure Impairs Weight Gain, Reproduction, Blood Glucose Levels, and Organ Health in Rats (Rattus norvegicus). https://www.wisdomgale.com/jelm/?mno=231340 [Access: April 02, 2025]. doi:10.5455/JELM.20241203024659

AMA (American Medical Association) Style

Yahaya TO, Salisu TF, Musa K, Sani H, Tadi S, Shemishere U, Daniel A, Muhammad N. Microplastic Exposure Impairs Weight Gain, Reproduction, Blood Glucose Levels, and Organ Health in Rats (Rattus norvegicus). J Exp Lab Med. Online First: 25 Feb, 2025. doi:10.5455/JELM.20241203024659


Vancouver/ICMJE Style

Yahaya TO, Salisu TF, Musa K, Sani H, Tadi S, Shemishere U, Daniel A, Muhammad N. Microplastic Exposure Impairs Weight Gain, Reproduction, Blood Glucose Levels, and Organ Health in Rats (Rattus norvegicus). J Exp Lab Med, [cited April 02, 2025]; Online First: 25 Feb, 2025. doi:10.5455/JELM.20241203024659


Harvard Style

Yahaya, T. O., Salisu, . T. F., Musa, . K., Sani, . H., Tadi, . S., Shemishere, . U., Daniel, . A. & Muhammad, . N. (2025) Microplastic Exposure Impairs Weight Gain, Reproduction, Blood Glucose Levels, and Organ Health in Rats (Rattus norvegicus). J Exp Lab Med, Online First: 25 Feb, 2025. doi:10.5455/JELM.20241203024659


Turabian Style

Yahaya, Tajudeen Olanrewaju, Titilola Fausat Salisu, Kabiru Musa, Hindatu Sani, Samuel Tadi, Ufuoma Shemishere, Anyebe Daniel, and Nasiru Muhammad. 2025. Microplastic Exposure Impairs Weight Gain, Reproduction, Blood Glucose Levels, and Organ Health in Rats (Rattus norvegicus). Journal of Experimental and Laboratory Medicine, Online First: 25 Feb, 2025. doi:10.5455/JELM.20241203024659


Chicago Style

Yahaya, Tajudeen Olanrewaju, Titilola Fausat Salisu, Kabiru Musa, Hindatu Sani, Samuel Tadi, Ufuoma Shemishere, Anyebe Daniel, and Nasiru Muhammad. "Microplastic Exposure Impairs Weight Gain, Reproduction, Blood Glucose Levels, and Organ Health in Rats (Rattus norvegicus)." Journal of Experimental and Laboratory Medicine Online First: 25 Feb, 2025. doi:10.5455/JELM.20241203024659


MLA (The Modern Language Association) Style

Yahaya, Tajudeen Olanrewaju, Titilola Fausat Salisu, Kabiru Musa, Hindatu Sani, Samuel Tadi, Ufuoma Shemishere, Anyebe Daniel, and Nasiru Muhammad. "Microplastic Exposure Impairs Weight Gain, Reproduction, Blood Glucose Levels, and Organ Health in Rats (Rattus norvegicus)." Journal of Experimental and Laboratory Medicine Online First: 25 Feb, 2025. Web. 02 Apr 2025 doi:10.5455/JELM.20241203024659


APA (American Psychological Association) Style

Yahaya, T. O., Salisu, . T. F., Musa, . K., Sani, . H., Tadi, . S., Shemishere, . U., Daniel, . A. & Muhammad, . N. (2025) Microplastic Exposure Impairs Weight Gain, Reproduction, Blood Glucose Levels, and Organ Health in Rats (Rattus norvegicus). Journal of Experimental and Laboratory Medicine, Online First: 25 Feb, 2025. doi:10.5455/JELM.20241203024659


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