Abstract
This mini-review explores the transformative potential of technological advancements and innovation in shaping the future of general surgery. Artificial intelligence, robotics, bioprinting, gene editing, and nanotechnology hold immense promise for enhancing surgical precision, minimizing complications, and personalizing patient care. However, the review acknowledges the ongoing challenges of global surgery, particularly the need for solutions to bridge the gap in access to safe and effective surgical care for underserved populations. Telemedicine and mobile health platforms emerge as promising tools for delivering surgical consultations and follow-up care in resource-limited settings. Ethical considerations, including resource allocation, research conduct, and cultural competency, are recognized as crucial aspects of global surgery. Collaborative frameworks that prioritize equity and empower local communities are emphasized. The potential impact of climate change on surgical needs is also addressed, highlighting the importance of understanding this interplay to develop preparedness and mitigation strategies. Finally, the review explores unconventional topics with the potential to changing the shape of surgical practices, including the role of the gut microbiome, psychedelic substances, and personalized genetic approaches. The importance of further research in these areas is acknowledged. In conclusion, this article portrays a future of general surgery characterized by a fusion of cutting-edge technology, a commitment to global health equity, and a focus on ethical considerations and responsible innovation. This future holds immense promise for improved surgical outcomes, enhanced patient care, and a more equitable distribution of surgical resources across the globe.

Key words: Artificial Intelligence, Robotics, Bioprinting, Gene Editing, Nanotechnology, Telemedicine, Mobile Health, Psychedelic Medicine, Personalized Surgery, Surgeons