Route-specific pharmacokinetics and bioavailability of Nitrofuran antibiotics in Sonali chicken predict veterinary therapeutic efficacy and residual effects for public health

Plabon Ketan Barua; Uaye  Mya; Khadija  Begum; Amir Hossan Shaikat

doi:10.5455/JRVS.20250324052359

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Original Article
Online Published: 02 Apr 2025

J Res Vet Sci. 2025; 5(2): 116-121

doi: 10.5455/JRVS.20250324052359

Route-specific pharmacokinetics and bioavailability of Nitrofuran antibiotics in Sonali chicken predict veterinary therapeutic efficacy and residual effects for public health

Plabon Ketan Barua, Uaye Mya, Khadija Begum, Amir Hossan Shaikat.

Abstract
Aim: This study investigates the bioavailability and pharmacokinetics of nitrofuran antibiotics in Sonali chickens, comparing four administration routes: oral (PO), intravenous (IV), subcutaneous (SC), and intramuscular (IM). Understanding these pharmacokinetic properties is crucial for optimizing therapeutic efficacy and minimizing residue risks in food safety.
Methods: Four Sonali chickens were included in the study. Three chickens received 1 mL of nitrofuran (25 ng/mL) via PO, SC, and IM routes, while one was administered 2 ng/mL intravenously. Plasma samples were collected at predetermined intervals, and pharmacokinetic parameters such as plasma clearance rate and drug retention were analyzed.
Results: Significant differences in bioavailability and pharmacokinetics were observed among the administration routes. The PO route exhibited rapid plasma concentration decline, with a clearance rate of 1.525 h⁻¹. In contrast, the IV route showed a slower reduction (0.662 h⁻¹) despite a lower administered dose. The SC route maintained higher plasma concentrations throughout the study, with the lowest clearance rate (0.280 h⁻¹), indicating prolonged drug retention. The IM route demonstrated a unique pattern with a transient plasma concentration increase at the second hour and a negative clearance rate (-0.701 h⁻¹), suggesting drug deposition in edible tissues, potentially contributing to antimicrobial resistance (AMR).
Conclusion: This study highlights the influence of administration routes on the bioavailability and elimination of nitrofuran antibiotics in Sonali chickens. The findings emphasize the need for careful selection of administration routes to balance therapeutic effectiveness while mitigating residue risks and AMR concerns in poultry production.

Key words: Antimicrobial Resistance, bioavailability, ELISA, pharmacokinetics

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Pubmed Style

Barua PK, Mya U, Begum K, Shaikat AH. Route-specific pharmacokinetics and bioavailability of Nitrofuran antibiotics in Sonali chicken predict veterinary therapeutic efficacy and residual effects for public health. J Res Vet Sci. 2025; 5(2): 116-121. doi:10.5455/JRVS.20250324052359

Web Style

Barua PK, Mya U, Begum K, Shaikat AH. Route-specific pharmacokinetics and bioavailability of Nitrofuran antibiotics in Sonali chicken predict veterinary therapeutic efficacy and residual effects for public health. https://www.wisdomgale.com/jrvs/?mno=248977 [Access: April 22, 2025]. doi:10.5455/JRVS.20250324052359

AMA (American Medical Association) Style

Barua PK, Mya U, Begum K, Shaikat AH. Route-specific pharmacokinetics and bioavailability of Nitrofuran antibiotics in Sonali chicken predict veterinary therapeutic efficacy and residual effects for public health. J Res Vet Sci. 2025; 5(2): 116-121. doi:10.5455/JRVS.20250324052359

Vancouver/ICMJE Style

Barua PK, Mya U, Begum K, Shaikat AH. Route-specific pharmacokinetics and bioavailability of Nitrofuran antibiotics in Sonali chicken predict veterinary therapeutic efficacy and residual effects for public health. J Res Vet Sci. (2025), [cited April 22, 2025]; 5(2): 116-121. doi:10.5455/JRVS.20250324052359

Harvard Style

Barua, P. K., Mya, . U., Begum, . K. & Shaikat, . A. H. (2025) Route-specific pharmacokinetics and bioavailability of Nitrofuran antibiotics in Sonali chicken predict veterinary therapeutic efficacy and residual effects for public health. J Res Vet Sci, 5 (2), 116-121. doi:10.5455/JRVS.20250324052359

Turabian Style

Barua, Plabon Ketan, Uaye Mya, Khadija Begum, and Amir Hossan Shaikat. 2025. Route-specific pharmacokinetics and bioavailability of Nitrofuran antibiotics in Sonali chicken predict veterinary therapeutic efficacy and residual effects for public health. Journal of Research in Veterinary Sciences, 5 (2), 116-121. doi:10.5455/JRVS.20250324052359

Chicago Style

Barua, Plabon Ketan, Uaye Mya, Khadija Begum, and Amir Hossan Shaikat. "Route-specific pharmacokinetics and bioavailability of Nitrofuran antibiotics in Sonali chicken predict veterinary therapeutic efficacy and residual effects for public health." Journal of Research in Veterinary Sciences 5 (2025), 116-121. doi:10.5455/JRVS.20250324052359

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

Barua, P. K., Mya, . U., Begum, . K. & Shaikat, . A. H. (2025) Route-specific pharmacokinetics and bioavailability of Nitrofuran antibiotics in Sonali chicken predict veterinary therapeutic efficacy and residual effects for public health. Journal of Research in Veterinary Sciences, 5 (2), 116-121. doi:10.5455/JRVS.20250324052359

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