E-ISSN 3041-5594
 

Case Report
Online Published: 18 Dec 2024
 


Uncommon Case of Light Chain Primary Amyloidosis with Negative Bence Jones Protein and Positive Congo Red Stain in A 31 Years Old Sudanese Patient

Mujahed Nooraldaem Mirghani Adam, ismail Osman Khalid, ali Seedahmed Mohamed Ali, alkhair Abd Almahmoud Idris.


Abstract
A 31 years old male non diabetic or hypertensive, medically free who had unremarkable part of mild hepatosplenomegally, loss of weight and immunoglobulin light chain (AL) Amyloidosis. This patient underwent Trephine biopsy and Bone Marrow aspiration to confirm the diagnosis. Light microscopy showed deposition of Amyloid, focal areas with excess infiltration by plasma cells, cytoplasmic and background infiltration by eosinophilic materials is noted in Trephine biopsy without fibrosis. slightly blood diluted bone marrow aspirate with scattered granulocytes and plasma cells. Touch imprint showed hypercellular bone marrow with excess infiltration by plasma cells around 34% abnormal form and marked interstitial deposition of hyaline material Amyloids are noted. Overactive granulopoiesis with ordered maturation, increased eosinophils. Bence Jones protein was negative in the urine. We finally diagnosed this patient as having primary AL Amyloidosis by Congo red staining under polarizing microscope and started the treatment.

Key words: Light Chain, Primary Amyloidosis, Bence Jones Protein, Sudan


 
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How to Cite this Article
Pubmed Style

Adam MNM, Khalid iO, Ali aSM, Idris aAA. Uncommon Case of Light Chain Primary Amyloidosis with Negative Bence Jones Protein and Positive Congo Red Stain in A 31 Years Old Sudanese Patient. Case Rep Ser Med. 2024; 1(3): 51-54. doi:10.5455/CRSM.20241124010509


Web Style

Adam MNM, Khalid iO, Ali aSM, Idris aAA. Uncommon Case of Light Chain Primary Amyloidosis with Negative Bence Jones Protein and Positive Congo Red Stain in A 31 Years Old Sudanese Patient. https://www.wisdomgale.com/crsm/?mno=302657757 [Access: December 28, 2024]. doi:10.5455/CRSM.20241124010509


AMA (American Medical Association) Style

Adam MNM, Khalid iO, Ali aSM, Idris aAA. Uncommon Case of Light Chain Primary Amyloidosis with Negative Bence Jones Protein and Positive Congo Red Stain in A 31 Years Old Sudanese Patient. Case Rep Ser Med. 2024; 1(3): 51-54. doi:10.5455/CRSM.20241124010509



Vancouver/ICMJE Style

Adam MNM, Khalid iO, Ali aSM, Idris aAA. Uncommon Case of Light Chain Primary Amyloidosis with Negative Bence Jones Protein and Positive Congo Red Stain in A 31 Years Old Sudanese Patient. Case Rep Ser Med. (2024), [cited December 28, 2024]; 1(3): 51-54. doi:10.5455/CRSM.20241124010509



Harvard Style

Adam, M. N. M., Khalid, . i. O., Ali, . a. S. M. & Idris, . a. A. A. (2024) Uncommon Case of Light Chain Primary Amyloidosis with Negative Bence Jones Protein and Positive Congo Red Stain in A 31 Years Old Sudanese Patient. Case Rep Ser Med, 1 (3), 51-54. doi:10.5455/CRSM.20241124010509



Turabian Style

Adam, Mujahed Nooraldaem Mirghani, ismail Osman Khalid, ali Seedahmed Mohamed Ali, and alkhair Abd Almahmoud Idris. 2024. Uncommon Case of Light Chain Primary Amyloidosis with Negative Bence Jones Protein and Positive Congo Red Stain in A 31 Years Old Sudanese Patient. Case Reports and Series in Medicine, 1 (3), 51-54. doi:10.5455/CRSM.20241124010509



Chicago Style

Adam, Mujahed Nooraldaem Mirghani, ismail Osman Khalid, ali Seedahmed Mohamed Ali, and alkhair Abd Almahmoud Idris. "Uncommon Case of Light Chain Primary Amyloidosis with Negative Bence Jones Protein and Positive Congo Red Stain in A 31 Years Old Sudanese Patient." Case Reports and Series in Medicine 1 (2024), 51-54. doi:10.5455/CRSM.20241124010509



MLA (The Modern Language Association) Style

Adam, Mujahed Nooraldaem Mirghani, ismail Osman Khalid, ali Seedahmed Mohamed Ali, and alkhair Abd Almahmoud Idris. "Uncommon Case of Light Chain Primary Amyloidosis with Negative Bence Jones Protein and Positive Congo Red Stain in A 31 Years Old Sudanese Patient." Case Reports and Series in Medicine 1.3 (2024), 51-54. Print. doi:10.5455/CRSM.20241124010509



APA (American Psychological Association) Style

Adam, M. N. M., Khalid, . i. O., Ali, . a. S. M. & Idris, . a. A. A. (2024) Uncommon Case of Light Chain Primary Amyloidosis with Negative Bence Jones Protein and Positive Congo Red Stain in A 31 Years Old Sudanese Patient. Case Reports and Series in Medicine, 1 (3), 51-54. doi:10.5455/CRSM.20241124010509